Human Being have always been in search of happiness and meaning. As St. Augustine well expressed it: "They want to be happy even living a life that will not make them so" (De Civitate Dei, XIV, 4). This statement already poses the problem of the tension between profound desire and moral choices, whether conscious or not. Pascal aptly describes this tension: "If human beings are not made for God, why do they show themselves so averse to God?" (Pensees, II, 169). In presenting this reflection on the delicate subject of the relationship between the Bible and morality the Biblical Commission premises two crucial propositions: 1- or every believer and for very person God is the ultimate answer to this search for happiness and meaning. 2-the one Holy Scripture, comprising both Testaments, is a valid and useful locus of dialogue with our contemporaries on questions concerning morality.